OT: 83rd Obsequious Banter Thread: Balls to the Wall

[Embiid]

Think he just cashed in a lifetime of luck

'Oh My God, I'm In A Whale's Mouth': Lobster Diver Says He Was Nearly Swallowed By Whale Off Cape Cod

 

[Jack Straw]

 

[DancingPanther]

The issue is that they had all of two clinical trials one of which showed some benefit and another that showed no benefit at all. So it is not conclusive that the drug is safe or effective for that matter. If you read the transcript of the interview I posted or listen to it this is a key part...

And as far as between the doc and patient more like between the doc and pharma rep...lol


So the cost benefit analysis will really be done in the next 3-5 years...hopefully not too many people will be "butthurt"...

They didn't have "all but" 2 clinical trials. The 2 clinical trials everyone is talking about are the pivotal trials which are the studies submitted to the FDA for approval. There were phase 1 trial(s) on healthy people before that for dose floors and ceilings and safety and pharmacokinetics, phase 2 trial(s) for efficacy, and the two largest, most robust phase 3 trials for safety and efficacy which are used as the pivotal trials. This is normal drug development.

Yes, it boils down to risk vs benefit. Which is what healthcare in general boils down to. But again, you have to start somewhere with an orphan drug/disease. This to me, in my expertish (that is, non-neuro-specialist) opinion, is a fine place to start.

The nature of Alzheimers is prospective anyway. These patients will need to be followed, and I hope to see this drug given to early stage patients in a phase 4 trial post-approval, which some medications also are subject to

 

[Embiid]

They didn't have "all but" 2 clinical trials. The 2 clinical trials everyone is talking about are the pivotal trials which are the studies submitted to the FDA for approval. There were phase 1 trial(s) on healthy people before that for dose floors and ceilings and safety, phase 2 trial(s) for efficacy, and the two largest, most robust phase 3 trials for safety and efficacy which are used as the pivotal trials. This is normal drug development.

Yes, it boils down to risk vs benefit. Which is what healthcare in general boils down to. But again, you have to start somewhere with an orphan drug/disease. This to me, in my expertish (that is, non-neuro-specialist) opinion, is a fine place to start.

The nature of Alzheimers is prospective anyway. These patients will need to be followed, and I hope to see this drug given to early stage patients in a phase 4 trial post-approval, which some medications also are subject to

There is another variable FDA doesn't get involved with ..cost to Medicare, Medicaid/states based on the drug's cost. Why drug prices need to be negotiated like the VA does..

The Drug That Could Break American Health Care

 

[DancingPanther]

There is another variable FDA doesn't get involved with ..cost to Medicare, Medicaid/states based on the drug's cost. Why drug prices need to be negotiated like the VA does..

The Drug That Could Break American Health Care

Not everyone with Alzheimer's will be prescribed this drug. This "worst case scenario" is just fearmongering. Besides, many times there are manufacturer related relief programs for these very expensive medications. The funny part about this is it just goes to show, once again, how broken the American "healthcare" "system" is.

 

[CanadianFlyer88]

My wife helped the gremlin make a menu so that she could cook us meals in her toy kitchen. The menu was made on Paw Patrol paper, so I ordered a broiled pup as a joke last night.

Just now, after picking her up from daycare, she offers me broiled pup out of the blue.

I regret nothing.

 

[Surrounded By Ahos]

My wife helped the gremlin make a menu so that she could cook us meals in her toy kitchen. The menu was made on Paw Patrol paper, so I ordered a broiled pup as a joke last night.

Just now, after picking her up from daycare, she offers me broiled pup out of the blue.

I regret nothing.

Did she source the meat from beef's in-laws?

 

[Rebels57]

In the Heights was great - an injection of life into my barren soul

 

[Embiid]

Funny if BTS causes the downfall of the Hermit Kingdom..and Kim Jong Un..

Kim Jong-un Fears K-Pop Taking Over, Cracks Down on 'Vicious Cancer'

 

[Amorgus]

Holy shit.

The in-laws are putting down their lab tomorrow. It is time. Beefette explains this to The Child. She tells Meatbelle that the dogs body is broken, so a vet is coming to make her feel better but it means she will die and we won't see her again.

This f***ing savage ponders it and replies, "Can I see her broken body?"

My friend's daughter is just like this and I love her to death. She apparently leaned over to her mom a day or two ago and whispered "I can feel my tender meat under my skin.". Can't wait to see her today but hope she doesn't step on my mangled toes while getting literally up in my face and asking me about my flaws.

 

[Surrounded By Ahos]

You guys want to see the weirdest bathroom ever?

 

[Magua]

You guys want to see the weirdest bathroom ever?

View attachment 446341

I hoped someone walked in while you were taking a picture of a public bathroom.

 

[Surrounded By Ahos]

I hoped someone walked in while you were taking a picture of a public bathroom.

Unfortunately I haven’t seen this monstrosity in person, I found it on Twitter.

 

[Beef Invictus]

Unfortunately I haven’t seen this monstrosity in person, I found it on Twitter.

This is the kind of bathroom you find after you open a Hellraiser box and wander through the door.

 

[Surrounded By Ahos]

This is the kind of bathroom you find after you open a Hellraiser box and wander through the door.

I’m in awe of just about everything. The yellow tile that looks like leaky piss, the stacks of tp over the toilets, the sink that looks like it used to double as a urinal trough, the f***ing window. It’s a masterpiece. I refuse to believe that it was created by human hands.

 

[Beef Invictus]

I’m in awe of just about everything. The yellow tile that looks like leaky piss, the stacks of tp over the toilets, the sink that looks like it used to double as a urinalysis trough, the f***ing window. It’s a masterpiece. I refuse to believe that it was created by human hands.

It was built in Tiger Pants' home state. This is how people like him do

 

[BackToTheBrierePatch]

I’m in awe of just about everything. The yellow tile that looks like leaky piss, the stacks of tp over the toilets, the sink that looks like it used to double as a urinal trough, the f***ing window. It’s a masterpiece. I refuse to believe that it was created by human hands.

Not saying it was aliens but yeah aliens

 

[Captain Dave Poulin]

It was built in Tiger Pants' home state. This is how people like him do

This seems unnecessary.

 

[Magua]

Unfortunately I haven’t seen this monstrosity in person, I found it on Twitter.

My favorite part is the double toilet stall without doors, while the wide open bathroom door — for any passersby — peers down upon them. But not only that: both of those toilets have urine in them on the video. So, someone chose to use each of those most public of public toilets and then not even flush. Who are those people? I use the word “people” loosely.

 

[Surrounded By Ahos]

My favorite part is the double toilet stall without doors, while the wide open bathroom door — for any passersby — peers down upon them. But not only that: both of those toilets have urine in them on the video. So, someone chose to use each of those most public of public toilets. Who are those people?

If I was there, I would totally use the creepy toilet at the bottom of the stairs.

 

[Embiid]

Unfortunately I haven’t seen this monstrosity in person, I found it on Twitter.

My HS bathroom wasn't much better...stalls with no doors b/c people would smoke in the bathroom so they thought removing the doors would discourage it....well it didn't ...just discouraged people from wanting to take a shit!

 

[Flybynite]

 

[Lord Defect]

If I was there, I would totally use the creepy toilet at the bottom of the stairs.

How could you not?

 

[Captain Dave Poulin]

"NBC has announced that the show will now be re-branded as 'Ultimate Shit 'N Slide.'"

 

[sabremike]

This is the kind of bathroom you find after you open a Hellraiser box and wander through the door.

In hindsight it probably wasn't a good idea to allow Chuck Berry to design it.