I don't have a problem with those D pairings really. I think it's been forgotten that EJ and Cole were great together against the Flames. Completely neutralized Gaudreau, Monahan, and Lindholm with strong, physical, playoff style defense. They're going to need that against the big bodies of the Sharks in front of the net.
Puck movement is the area I'd be concerned with for that pairing, not having Girard, Barrie, or Makar with those two. Maybe this gets EJ into the game though. When he's on his horse carrying the puck up ice, he's at his best.
Not overly concerened with a Girard-Makar pairing. Out of the three puck moving D men, G has the best defensive awareness, and plays a really cerebral game. As opposed to a Makar-Barrie pairing, I think/hope G will have a good awareness of when to be aggressive, and when to sit back and cover for his partner. His great, active stick will hopefully help him cover for any defensive hiccups from the young Makar as well.
A heavy, physical forecheck will be the area of concern for them. The Sharks have no problems just dumping pucks in and finishing their checks to get the puck back. G didn't look 100% to me last game, and Makar is still getting used to the pace of both neutral and D zone forechecks. Hopefully they drilled the heck out of puck retrievals yesterday though, because they're going to need to get to pucks quickly, and get them out of harms way effectively.
I think Girard-Makar have a chance at forming a really good pairing if they click together though. They're both so smart and creative, they could end up dominating with the puck, and still have the proper awareness to play well defensively.