I don't know if the NFL teams that went though it are direct comparables, but a few teams were put in pretty bad situations.
The Tennessee Titans had 24 players get Covid, though the outbreak was stretched out a bit longer and of course they would have more players on the team. It did cause major disruptions to the schedule. I would have to look back but they would have went through extremely long periods with little to no practice time, similar to the Canucks.
The Denver Broncos found out the day before their game that one of their QBs tested positive and all of their other QBs were close contacts so they had no QBs and had to put a WR in at QB. I don't know what you would compare it to on the Canucks, maybe if their entire defense core was out due to Covid. Awful and a no-win situation, essentially forfeit the game which is pretty key in a 16 game season.
I don't think either situation is as bad as the Canucks but they weren't great either.
Point is, I don't think the Canucks situation is particularly unique other than they had more players get it and for whatever reason didn't call anyone up from the minors despite having enough time to do so.
The NFL situation was nothing like the situation with the Canucks.
With the Canucks, we're talking, what, 21 players had it? Their full roster was 23, though the 21 included some from the taxi squad. In any event, take away the players that had it and there is no way the Canucks could ice a full team.
The NFL roster is 53 players. Take away the players that had it on the Titans and you still have enough for a full offence and a full defence with a few reserves even before bringing in other players.
Hockey is so intensive that subs are necessary so that players don't collapse from exhaustion. Football isn't so intensive and in olden days there were players that would play the whole game. Of course, in football players only exert themselves a few seconds at a time, then wait for the officials to place the ball, then huddle for play calling, then exert themselves for a few seconds again.
The difference in the nature of the game and in the number of players on the roster makes it completely different from the Canucks, who would have to ice their barely recovered players, who would be expected to be deficient in respiration.
I don't see any comparison at all between almost the whole team being sick and a team missing it's quarterbacks. The team missing it's quarterbacks is very likely to lose, though probably not as badly as the Canucks would stand to lose. On the other hand, the Broncos' players on the field wouldn't be suffering from respiratory issues and be as susceptible to injury.
About the only similarity I see with the football situations is that they were both covid related.