Reus won't play against Spurs. He's out for ten days with a muscle injury.
Its hard to tell how we'll line up.
Piszczek is questionable due to ongoing ankle problems. He's been really good this season, and having him out injured would be another big injury. They are easing Zagadou back in after he missed almost two months, but the backline has been terrible recently, so they might scrap that plan and throw him back in. Akanji returned to training yesterday, but won't be fit for tomorrow's game.
My preferred back line would be Piszczek-Toprak-Zagadou-Hakimi, but we could just as easily see Weigl-Diallo in central defense. If Piszczek can't play, Hakimi will play RB, and Schmelzer or Diallo will come in at LB.
The Reus injury should be a very easy situation to sort out, but Favre has been stubborn with where he uses Goetze. It should be Goetze takes Reus spot, and Alcacer plays from the start. Favre doesn't like using Goetze in his best position, so it might be one of Alcacer/Goetze as the striker. He's been using Philipp in the Reus role, but Philipp does nothing in that position, and it would be dumb to try it again. Guerreiro could play that role better, if he insists on not using Goetze there. We could then bring Pulisic or Philipp in at Guerreiro's LW position.