Obviously the big wildcard here is who we draft, but Matthews would be amazing. If we get him, I think we deal Bozak, and keep just one of Holland/Laich. I also see Nylander at centre, not on the wing. In the dream "draft Matthews" scenario, I'd go with something like:
JVR - Kadri - Komarov
Soshnikov - Nylander - UFA/trade
Leivo - Matthews - Marner
Leipsic - Holland/Laich - Hyman
Hunwick - Rielly
Gardiner - Zaitsev
UFA/trade - Carrick
Bernier
Sparks
That may be unrealistically young, but I think a lot of these young guns are better than some of our weak older players like Lupul, Greening, Michalek, etc., not hard to imagine all of those being waived. Marincin I think is also pretty borderline, wouldn't be hard to find a better UFA to fill his spot. Marner's a big question mark, who knows if he makes the team, but I can see him getting there, especially since another year in London would be a bit of a waste for him, he's just too good for the OHL and won't be properly challenged.
Also, if we get Matthews (HUGE "if"), eventually the centre rotation would reverse (Matthews 1C, Nylander 2C, Kadri 3C), but just for next season I'd expect Kadri > Nylander > Matthews.