I wouldn't say it's comparable. Losing your 1 and 2 D and 3 top 6 forwards all for months isn't something you see everyday.
However, that's just life and I would agree that you can;t really use it as an excuse, even though we hear people do it with teams all the time. It's the aspect of winning cups we rarely talk about - luck.
Wait, wait, are we talking about the Leafs, or are we talking about Seth Jones, Ryan Murray, Zach Werenski (albeit for only a couple weeks), Bjork, Atkinson, and Anderson? Not to mention Korpi in net and countless depth players.
I'm not trying to make this a pissing match about who has the worst injuries, but it is definitely a waste of an excuse to pretend the Leafs have some sort of entitled claim to being the better team because of injuries. Columbus could flip the narrative so easily.
"We lost our top two D men for significant time" - Well, Columbus has lost a lot more man games lost to injury than them, and with significant players, too.
"You can't discount Sheldon Keefe just because he's new, we blame our old coach" - Well, you can't say Andersen is a better goalie than Elvis either, in that case. Elvis has been a relevant NHL goalie about as long as your coach, with better save % than Andersen. As has been pointed out, Keefe's point % since the new year is not as high as Torts.
"We're better because we have 3 more wins" - Well, imagine if Columbus won even half of their 3 on 3 or shootout games? Then they'd be ahead of Toronto in the standings. I don't think 3 on 3 or shootout numbers matter much come playoff time.
"Top end talent" - I give the Leafs an edge in overall talent, sure. But if the rosters were reversed, Leafs fans and TSN would be touting Jones/Werenksi as basically the defensive version of what they call Matthews and Marner. There isn't some giant gap in talent like some choose to believe. Columbus' style is different, for sure, but it's given them pretty much the exact results this year as the Leafs.
I see this as basically a coin flip of a series, just like the standings would dictate, and I'm already salivating at being able to watch it. It will be exciting hockey by two good teams. But can we stop pretending the Leafs have all these ready made excuses for why they should have more respect than anyone else? Both teams can pick and choose to argue their own narrative, or to make excuses, forever.