I don't think it's a good idea to split up the top line... But if we are going to be experimental especially early in the year to see what we have in some kids, I'd like to see something like this:
LOC - Mack - Rantanen
Landy - Newhook - Compher
Nuke - Kadri - Burakovsky
Helm - Jost - Maltsev
Byram - Makar
Toews - Girard
Murray - EJ
My reasoning is this: You give Newhook time as the 2C to really find out if he is A) Capable of that role now or B) If he could be sooner then later. Finding this information out would be critical for determining whether we need to go after another 2C at the deadline this year or if Newhook can be that guy. Putting Landy on his week would give him the best two way winger on the team allowing him to focus more on the offensive side of the game and seeing if he can be productive in that role. I chose Landy rather then Nichuskin here because Nuke is probably better defensively but is a black hole on offense which wouldn't help Newhook either.
Beyond that, we also already know Nuke/Kadri/Bura works very well as a line so Putting that trio together allows consistency out of the 3rd line during the Newhook experiment.
LOC goes to the 1st line because I think his speed and tenacity on the forecheck as well as strong defensive play would do the best to replace what Landy brings on that top line. And I know I'm probably in the minority here with this but I really, really think LoC is a guy who will only continue to surprise the more responsibility he gets. His trajectory reminds me more and more of Blake Coleman and it would not surprise me in the least if he were to put up 20 Goals and 40 points if he ended up playing with Mack and Mikko long term this year.
The weak point in the lineup is probably JTC as the 2RW. But you hope in this experiment that Newhook does really well and instead of having to focus on a 2/3C at the deadline, you can turn your focus to a much cheaper to acquire winger for that 2nd line instead(I already envision a JTC++ for Rakell trade here for us).
On the defense, pair Byram with Makar and see how he does. Sink or swim sort of situation. If he does well in that role it could at least opens up more options for the Defense in terms of potential trades to fill other holes later on.
I really don't like G on the right side and in the playoffs especially I think he and EJ need to be a pairing that don't get touched(Assuming EJ is healthy) But for a stretches against weaker teams I think G is probably fine on the right side.
I'm sure injuries will be a regular theme again next year considering the roster we have... But I would like or hope to see Ranta and Barron get at least ~15 games in the NHL as I think both are really good bets to fill depth roles for us next year(I see Ranta as a bottom 6 Winger next season and Barron taking that 3RD spot). I'd also hope to see Foudy get a look(Potential 4C as soon as next year) and if Olausson is in the AHL I think he gets some games as well tbh.