Looking at the most recent starting XIs, I have it as such
De Gea = Ramsdale. De Gea the better shot stopper when he's on his game but Ramsdale's feet are important to Arsenal.
Wan-Bissaka < White. Wan-Bissaka is going through a minor renaissance but is useless going forward.
Varane = Saliba. I think Saliba is slightly better but not enough to make a meaningful difference.
Shaw < Gabriel. If Martinez were here, it would be closer, but I still rate Gabriel over Martinez.
Malacia < Zinchenko. They play different games and I could see an argument that Malacia > Zinchenko in a different system. But Zinchenko fits the system like a glove.
Casemiro > Partey. It's close on form, but Casemiro is fantastic.
Fred < Xhaka. Fred manages to be more inconsistent than peak-inconsistent Xhaka and Xhaka has been consistently brilliant this year.
Fernandes < Saka. Bruno is great, Saka is better.
Eriksen < Odegaard. Odegaard has been the best player in the Prem this year. Eriksen is good too.
Rashford > Martinelli. On form, I think you have to go Rashford. I think Martinelli will be better in a year or two.
Martial > Nketiah. Nketiah has been fantastic deputizing for Jesus, but Martial is more talented, albeit more inconsistent.
Looking at the bench, Maguire, Martinez, Antony, Garnacho, McTominay vs. Tomiyasu, Tierney, El Neny, ESR, Vieira. I think Tomiyasu > Maguire, Martinez > Tierney, ESR=Antony, Garnacho > Vieira, El Neny=McTominay.
If I was making a combined two deep, assuming everyone is healthy, I go:
Jesus/Martial
Rashford/Martinelli - Odegaard/Fernandes - Saka/Garnacho
Casemiro/Partey - Xhaka/Fred
Zinchenko/Malacia - Saliba/Gabriel - Varane/Martinez - White/Tomiyasu
Ramsdale/De Gea