I'd really like to see:
Z - Datsyuk - Nyquist
Franzen - Weiss - Tatar
Helm - Sheahan - Abdelkader
Miller - Andersson - Glendending
Cleary
Jurco as a call-up, can play any W position on any line.
If Weiss can find his game of course. For once they'd have clear, effective lines and not just players randomly all over the lineup. #1 line scoring while shutting down opposing line, #2 for more scoring with a lot of different qualities, #3 for gritty, speedy 2-way game and #4 to bring more energy. I can see every line working when given the chance. Should also be a good team on the draw, since every line has 2 capable faceoff guys (except for #2 line but Tatar and Franzen can win draws surprisingly well).
Of course there's big risk of someone getting injured. Z, Datsyuk, Franzen, Weiss, Helm etc. But then there's more variations available.
If they just stuck with certain lines i think it would help a lot in the long run. But its Babcock...