For me it's like looking at the 2006/07 Pittsburgh Penguins, loaded with very young but very talented with high end stars. Greener than green, swept by the Ottawa Senators pretty much in 5 games in the first round.
Fast forward another year to 2007/08, they gain some much needed experience and beat teams they should considering their top talent level throughout the roster, com'n the Carolina Hurricanes in the conference finals....But only then, when they met up with a much more grizzled team in Detroit is where they were now back in unfamiliar territory and were caught in unknown for to much until it was too late to recover from.
By the time they got onto 2008/09 with the addition of players who been there and done that this team went onto the highest of highs. At this point there really wasn't any rookies per say. If you want to say Goligoski he'd be the only one. He played 2 games.
Check the roster for yourself.
http://en.wikipedia.org/wiki/2008%E2%80%9309_Pittsburgh_Penguins_season
So..Where I'm going with all of this, teams can go on to win with rookies, but most likely those are far and few between.(Exception of the rule) A couple of rookies shouldn't deter you from making a long run or keep you from the Stanley Cup, but if you load half of your squad up with them I wouldn't be looking for any cup aspirations. I would put the Pens somewhere between the 2006/07 and 2008/09 Penguins as they stand now, baring trades that may happen.
In short, don't expect to win the cup loaded with rookies. *Common sense*