I don't want to get into an argument of whether the Panthers deserve or don't deserve to be ranked where they are, because obviously I don't know enough to make a fair judgement, but I don't think the depth is as unique as you make it to be.
The Sabres, who are ranked #14 have Adam, Schiestel, Brennan, Pysyk, McNabb, Tropp and Gragnani from #3-#10. They have Sundher, who had 76points in the WHL, drafted 2010. Then they have Gauthier-Leduc, who was ranked second in this year's QMJHL scoring for d-men, drafted 2010, too. They've got a project d-man in Crawford who was, if I remember correctly, in the CHL's first all-star team a year ago and had a decent rookie season in the AHL. They have Paul Byron who's a little undersized, but looks like he's going to be a decent 3rd line center.
Obviously their top two prospects don't project to be as good as the Panthers' and their depth lasts only till about #20, but if we're strictly speaking about that middle prospect depth, then an average ranked team like the Sabres could hold their own against the Panthers.