For the long term I think the Nyquist, Zetterberg, Franzen line is working way too well to be split up. Abby slides in pretty much just fine when Franzen is down, honestly, which will probably happen a few more times this year.
Hard to match anyone up with Datsyuk. I actually like the idea of Helm on his wing, but we haven't really seen it yet too much. Tatar could be solid, but one of the reasons I think the kid line is so dangerous is his ability carrying the puck. Datsyuk would certainly take a majority of the zone entries and puck carrying duties on any line he's in, and I question whether that limits Tatar's effectiveness. Still, his shot is pretty damn lethal so he'd be nice to have with Datsyuk if he can get used to handling the puck a bit less.
Without Tatar I question the kid line's effectiveness. They really benefit from him holding onto the puck so much, and I'm not sure that Sheahan can have the same results taking over. Abdelkader and Jurco would be the logical linemates here, and (until Jurco develops a bit more) I'm just not sure that would be a very good possession line.
4th line will look good with whatever combination of Nestrasil, Miller, Glendening, and Andersson they trot out.
Based on this, I would actually love to try Jurco out with Datsyuk. Mantha would actually be my ideal player for the role in the organization, but obviously it's a bit early to think about that possibility. I don't think Babcock wold ever roll with this lineup, but I think it'd be solid:
Nyquist - Z - Franzen
Helm - Datsyuk - Jurco
Abby - Sheahan - Tatar
Miller - Glendening - Andersson/Nestrasil
Keeping Z/D together could still net you two great scoring lines with a Franzen/Nyquist duo on the second line, I'm just not sure I love any of our centers to fill that role on the team. If we want to give Weiss a shot at proving his worth, it'd be there. But that's just not going to happen with Babcock in charge, and with what we've seen it's not necessarily the wrong move either.