I'd say generally people who are multidimensional or can play more than one instrument. compose, produce, etc.
Jim O'Rourke as a guitarist, producer, sound manipulator, etc.
Prince
Miles Davis
Stevie Wonder (his drumming is underrated, he had unique feel and groove)
Quincy Jones
Todd Rundgren
Frank Zappa
Nile Rodgers
Joe Zawinul
John Frusciante
Andre 3000
Alain Johannes
Some shout outs to Madonna, Simon Green aka Bonobo, and then guys like Pepper Keenan (Corrosion of Conformity and down) and Brian Baker (Minor Threat, Bad Religion, Fake Names), and Phil Collins/Mike Rutherford from Genesis, and Keith Strickland from The B-52s who have done double duty or switched main instruments in bands based on circumstance.
I'll also show Dave Grohl some love. I'm not a fan of his always winking at the audience and public persona the last 25 years, and I like about three of the Foo Fighters albums, but he was able to become quite competent on the guitar and as a songwriter after his generation-changing drum work in Nirvana.