What's exciting is that Alfred Molina already confirmed that he is playing the exact same Doc OC from the second Spiderman movie, taken moments before his death, so they're not variants at all from the Multi-verse. Likewise Defoe...which could explain his surprised "oh" at the end of the first movie if they snap him back at the exact moment of his death.
I'm thrilled that those two are back, especiallly Defoe's Goblin, who was sensational in the role and carried the mixture of manipulative intellifence, charisma, and oozing menace. Some of the lines people have already mentioned ( Despite everything you've done for them, they will end up hating you, misrery, misery, misery is what you've chosen, you know I'm something of a scientist myself, first we attack his heart! etc) fit so well regarding Holland's character...I'm hoping for a massive beatdown scene where we end up with Holland getting dragged to a roof and getting lectured by Defoe. Another unintentionally hilarious scene where he blows up Aunt Mays wall and scares her while praying is too much to ask for
I think it's clear Dr. Strange was messing around with Peter performing that spell and was intending on teaching him a lesson, before something goes drastically wrong.
That lawyer slamming down the stack of files/papers onto the desk was 100% Charlie Cox as Matt Murdoch, who I'm almost excited to see as much as Defoe and Doc Oc!
"Hello Peter"...guaranteed he's saying that to Tobey's Spiderman over Holland's shoulder!
I haven't been this excited for a movie in a long long time ( possibly since Interstellar ), so I'll end off with simply saying "God speed Spiderman".