I am hoping the Leafs win against Florida, but I dont see them coming out of this road trip 3-0 so if I had to choose I would say lose against the Panthers (in OT if possible) but only if that guaranteed a win against Tampa.
Like someone else posted, these next 2 games are a gift from the hockey gods. Not often do you get to play a team in a downward spiral followed by a game against a playoff challenger that is severely depleted. The Leafs have to win that Tampa game. I believe that game will determine the rest of the way, a win creates a decent gap while Tampa will have trouble with injuries, but a loss would cause Tampa to leap frog Toronto and possibly catapult them with confidence for the last 15 games.