More often than not it's not too difficult to run, but each draft is different.
Some have 3 or 4 guys picking live, with a 10-20 lists, and then the obligatory MIA guys who just get auto'd. In these cases, easy enough.
It gets trickier when there are multiple trades within the round and we have 15+ guys picking live, and especially trades including other picks in the live rounds. I can't edit RR's posts, so I've just got to keep multiple windows open (during the 1st round I had 22 windows open including lists, draft orders, trade details, PM's indicating they'd be there live, etc) and check each one to see:
A) If the team is present
B) If they aren't, do they have a list
C) If there was a trade made with this team
Ultimately, it becomes a 2 man job for the live portion because of this. Usually I will do the selections and keep the order flowing, while RR will update the list based on trades and will then auto rounds 3 and 4. Good system we have going.
That said, we all have lives off the board, so sometimes things may take an extra day to flesh out. We'll be completing it tonight.