If this was last year's Chiefs i would give them a chance. Mahomes wasn't unbeatable and routinely played too much hero ball. This year's Mahomes is scarily locked in. It's almost like getting rid of Tyreek forced him to like, make reads and scan the field again instead of just relying on his stupidly gifted physical attributes.
Jacksonville's best hope is Lawrence shook off all the nerves/butterflies from being in the playoff in that Chargers game. I'd normally say putting a guy as young as Lawrence in the position where he has to match Mahomes pass for pass isn't a good idea, but the former has proven he's pretty god damn clutch already.
Game stays close through the first three quarters and then KC pulls away in the fourth. 34-21 Chiefs.