At the end of the day here's the realistic truth.
The only way we will ever see any realignment of this leagues divisions is through expansion. But even let's just play the game of one day the league does that you would have to expand the OHL evenly.
So how would they do that? Realistically this league would need to add even number of teams. Say 22 or 24 to balance the games which would also mean shaving games in divisional rivals down to accommodate a few teams.
As of right now every teams divisional schedule is a 6-6-8-8 breakdown of games being that the closer teams play more games while the futher away teams play a little bit less. Beyond the travel time and distance you would have to consider the fact that the league would have to change it's whole time frame and and it would be more of a nightmare for people in change.
Even if you realistically shuffle the divisions there would be teams that would be unhappy and someone would get the shirt end of the stick. Mainly those outlying teams like Ottawa, Soo, Windsor, and Erie.
So at the end of the day the only way will see any change will be minimal at best. Like even Hamilton to Brantford isn't a big inconvenience to teams and in some case a slight benefit to others.
This leaves the simple thought that "IF" and its a big "IF" the OHL was going to change things around you would have to think expansion into specific targeted markets would be key to a mass realignment. So what dies that mean, looking at old locations, (Belleville?, I doubt it they have the AHL, Detroit? Possible but highly unlikely, Toronto? I would think that is out of the question, Cornwall? Could but I think if Brantford is going to be the home of the Bulldogs that squashes that idea down.
That really leaves U.S. based places remaining, and with the way the AHL is located around I'd think that it would be more likely to see the OHL not bother trying to compete in a multi-market locals like that. So unless it's comes down to the day where teams that are already in the OHL relocating what we have now plus minus a tweak here or there will more likely remain the same, so in this case Hamilton to Brantford is a tweak that could have be temporary or permanent change in the OHL.
I would have to think this "temporary solution" could become a more permanent for the Bulldogs once they transition from Hamilton to Brantford.
It's like how fans wonder how Owen Sound makes a go of it in the OHL, we don't have a massive building but we also don't have a massive cost to upgrade and maintain the building also. Yes there's things that could be improved and at some point in the near future they will improve but for the city size we are it works.
So sum it all up if the OHL wanted to do any more juggling or relocating or teams around I think they had enough time to do that already, like 2 years of health shutdowns to sit there and decide what to do with the teams and who they'd play each week. And beyond the Bulldogs sort of getting the short end of the stick in Hamilton there's likely not going to be any significant changes league wide anytime soon.
In terms of expansion, Belleville, Cornwall, Brantford/Hamilton (depending how that goes) and either Chatham or another Michigan team are the spots I'd be looking at. If that were to happen, and alignment like this would seem to help just about everyone, save SSM who frankly, no matter what you do, will have the short end of the travel stick and Guelph who much like Mississauga and Hamilton, has relatively easy travel as is (although would loose the rivalry with Kitchener)
Ottawa, Cornwall, Kingston, Belleville, Peterborough, Oshawa
Guelph, Owen Sound, Mississauga, Barrie, Sudbury, North Bay
Brantford, Kitchener, London, Hamilton, Niagara, Erie
SSM, Saginaw, Flint, Windsor, Sarnia, Chatham/Ann Arbour/Plymouth?
That said, there's clear issues here in this whimsical scenario. Belleville is still hosting the Sens farm, Brantford and Hamilton is what it is and I believe Andlauer or any other owner could block both teams, Chatham I don't think has an arena of size, Ann Arbour's arena would be a university share and most of all, I don't see owners crawling out of the woodwork anywhere. That's what it my eyes makes Hamilton's situation especially awkward. Andlauer is a great owner, and unless the Ti-Cats suddenly decide to become Hamilton's OSEG or MLSE (which I suppose is possible, as they also own Forge FC and apparently have live nation connections, but I can't see them doing that till Forge breaks even) I don't know where these owners come from.
Like you said, there's likely not going to be any significant changes league wide anytime soon.