I've done the NJ to Orlando drive maybe 30 times in my life, give or take, so it is survivable.
If you were leaving during the day, I'd have some route hacks for you. Since you're leaving at night, the only suggestion I have is that when you get just outside of Richmond, Virginia, get off 95 and take 295 around Richmond back to 95, rather than simply staying on 95 through Richmond. Your GPS will tell you to stay on 95, but dont. It's about 5 miles longer on 295, but it's like the Autobahn and there's no traffic on that road, wont be accidents, etc... definitely saves time and is more relaxing.
I do the same thing in Jacksonville. Get off 95 and take 295 towards the beaches, then get back on 95 rather than staying on 95 the entire way straight through JAX. This one may or may not save time, but it's an easier drive and you may miss some JAX traffic and/or accidents from the hoards that remain on 95.