If Karlsson sustains something like this scoring pace, i think he takes the trophy home. Voters love a good "story", and his resurgence offers them a juicy narrative to go with.
Realistically, i'm not convinced he'll be able to sustain this all year though, and the Sharks as a team aren't going to be relevant as a playoff contender, so it'd have to be on Karlsson individually to stand out and shine.
So it's probably just Makar as the obvious "default" answer. Lindholm might get some attention and may even be a nominee as a novelty playing in a higher profile market now...But i doubt he puts together the point totals to win what amounts to the "scoring title for defencemen" trophy these days.