from what I gather...
brassard has much more speed, probably a better playmaker. I've heard comparisons to gagne, maybe a bit less of a scorer then him, better playmaker.
Little, is slower, average speed at the very best, gritty will go into corners, is a pure goal scorer, lots of garbage goals. Smart player. Compared to a briere maybe, marc savard?
I've only seen Little play and only twice. I came away impressed. Dunno about brassard, but most have glowing reports about him.