Lupul - Kadri - Kessel
Komarov - Bozak - Santorelli
JVR - Holland - Clarkson
Winnik - Smith - Booth/Panik
Based off of chemistry we've seen, and good meshes for style of play and role, I think these are the best lines to go with at this point in time.
Here is my rationale:
1st line: This line is the pure skill line. Lupul-Kessel have worked well in the past (it raised Lupul's game considerably - and would raise his eventual trade value), Kadri-Lupul works well, and Kadri-Kessel has shown flashes in their brief stints together. These are our 3 most individually skilled forwards, and while maybe not the best defensively on the wing, Kadri has developed a lot (his face-offs have also greatly improved) in that regard. The best defense is being able to control the puck offensively, and this line should be able to do that. If Carlyle does his job, they should also be going up against the secondary defensive pairings at every opportunity. This line has a passer (Kadri), a shooter (Lupul), and a hybrid (Kessel). This would ideally be deployed the same way that Chicago deploys the Kane line, or Boston deploys the Krejci line, or Anaheim deploys the Getzlaf line.
2nd line: This is the shutdown line. Komarov-Santorelli have been maybe our best pairing this year. They work off each other very well, relying heavily on the cycle, and Bozak should be able to fit into that style seamlessly. Bozak has taken that next step since the beginning of last year, and I think that he can finally hold his own away from Kessel. In fact, I think Bozak and Kessel are both better when apart. All 3 are anywhere from decent to great defensively, with Komarov being a key part of the PK and a great forechecker. These guys should be going up against the top offensive players on the opposing team every night, tasked with shutting them down. Both Bozak and Komarov should be very familiar with playing against these quality of players, and Santorelli has held his own against anything thrown at him this year. Bozak is also our best face-off guy, who is used to going up against the best opponents, which gives us an advantage. Komarov has shown to be great at getting players off their game. Who better than their stars? This would be deployed much like a Bergeron, Toews, Kesler line.
3rd line: This is our Hybrid line. JVR-Clarkson looked decent in their short stint together this season, and both Holland and Clarkson have looked their best while on the 3rd line. All 3 players are big at around 200 pounds, range from 6'1" to 6'3", can play physical, and should have an easier time barreling through weaker defensive pairings. Holland is not the greatest at face-offs, but he will now have two strong wingers that can help win the puck out of a scrum, while also going against guys that aren't necessarily as good at that aspect. This line should go against the weakest defensive pairings/forward lines on the other team. This also makes JVR the primary offensive guy on his line, which I think he needs. He has been putting up the points this year, but he has not been dominating games like we know he can and has in the past. I think he needs that push, and going against weaker defenses should also help. All 3 are capable of playing a strong north-south game and maintain possession with their size and strength. This also gives Holland somebody of skill to play with, so that we know what we have. Ideally, this line would be deployed similar to how Chicago, Anaheim, Boston deploy their 3rd lines, or how we deployed Kadri when he first joined the team in a permanent role (only hopefully we wouldn't have our other secondary line offensively dead).
4th line: This is our 4th line. Basically what else can you say. Primarily defensive guys who are needed for the PK. Winnik is our top guy in that regard. All 4 have shown flashes of offense in the past too. Booth was a 60 point guy at one time. Winnik held his own and made some nice plays when with Kessel. Smith helped us through our center disaster last year and played above expectations. And Panik has shown an ability to score with limited minutes this year. All have something to prove and/or a contract to play for. Personally, I would replace one of Smith/Booth/Panik with Kozun once he is healthy. He provided an incredible spark, and was a good PKer. Perfect 4th line guy. While they aren't going to do much offensively, and let's face it, probably won't get many 5 on 5 minutes, they will get PK time, and most importantly, they are good enough defensively that Carlyle doesn't need to be scared to put them out 5 on 5 should the need arise.