I think we drafted like 2 defensemen in the 2000s with 1st or 2nd round picks. One was ok (pitkanen) other busted (Marshall).
Its not like now where we will have a large sample size to look back on and compare who worked and didn't.
There was also
Jeff Woywitka (2001)- traded for Comrie, never amounted to anything more than a bottom pairer in the NHL
Mike Ratchuk (2006)- never played in NHL
Denis Bodrov (2006)- very briefly came over to play in AHL, never played in NHL
Luca Sbisa (2008)- traded for Pronger, hasn't amounted to anything spectacular
Seidenberg is the only other real standout from the entire rest of the decade in terms of defensemen, but he was drafted later than round 2.
A pile of crap for the most part.