Not unless America produces actual quality players of its own, substituting (comparatively) vastly overpaid old-and-not-very-good-anymore imports with genuine top class American players. I would say American and Canadian players, but Canada just seems incapable of producing anyone of any ability. To counter Butch's tired cliché above, the American population rallying behind the band of cloggers they had in the last World Cup shows you that any time there's some sort of national relevance, there will be national interest. Having actual, legitimate homegrown talent in the domestic leagues and the national team will see the interest following. I have many theories about how this could happen, but this isn't really the thread for them.
I would also suggest that given the apparent desire for European homogenisation among the Big Clubs that MLS doesn't have any hope of cracking the top ten, should such a scenario arise. If, for instance, you were to have some sort of close-shop pan-European arrangement guaranteeing the Big Clubs playing matches solely against each other all year round (in various places in the world, no doubt) then the revenues and popularity of that league would be unsurpassed in terms of the global revenues and audiences it would get. What was left of national leagues and associations would probably see a much more focused interest from its fans, making them less likely to have a genuine interest in anything outwith their country. I'm sceptical that such a competition could ever realistically exist, however. It certainly shouldn't, but then, money talks.
So to answer the question, I can't. There's no saying what football leagues will exist in the world over the course of my lifetime. What I would say though is that there will be no comparison at all between a league with a franchise system and leagues with genuine independent clubs in a meritocracy in terms of sustained local interest and relevance. Ever. Focus on sorting your own **** out rather than worrying about what the rest of the world thinks about you. North America certainly has the resources to be able to do it.
