It's Drai's to lose at this point.
McDavid has the better reputation.
If he comes back without missing too many games, and if he outplays Drai in the remaining games he's back, and if Oilers make playoffs, and if the Lindsay isn't voted too early in the year (I hear reports it gets voted on before end of year by many players) - McDavid will win. I know that's a lot of "if's", but i don't think any of them are unlikely.
If Drai however remains far atop the scoring race, and he outplays McDavid for rest of year, or at worst, they're seen as comparable - I think he'll win.
Someone else could potentially still step up to win, but in my mind it'll be one of them. Mack#3. Panarin will be ignored.