Nuke needs someone who can carry the offence on his line. If you start relying on him in any way offensively you’re in trouble. His defence is valuable, but his offence is not good.
Nichuskin - Kadri - Burakovsky
That should be our default 2nd line based on performance and analytics from last season. That line just clicks, with Burakovsky leading the transitions and Nichuskin sweeping up defensively, which allows Kadri to play that 'roving' sort of interpretation on the 2C role that he does. Kadri doesn't have to be elite defensively because Nichuskin is; nor does he have to be elite at transitioning the puck, because Burakovsky is so good at it.
With the top 6 set, go from there and find out which one of Compher/Donskoi/Jost/Calvert/Kaut has the best chemistry as a winger with Saad on the 3rd line. Also acquire a 3C.
Whoever is left, build as solid a 4th line as possible out of it.
Landeskog ---- Mackinnon ---- Rantanen
Nichuskin ------- Kadri --------- Burakovsky
Saad --------------- 3C ----------- Compher/Donskoi/Jost/Calvert/Kaut
xxxx ------------ Bellemare ----- xxxxx