OT: Coronavirus 3 - wait but Covid 19 is SARS-CoV-2

[MinJaBen]

Hopefully there are others with a similar story that will drive up the take rate on vaccines.

Hopefully. But then there are people who won't even wear a mask; how many of them are going to make time to go get a shot?

I hope I'm wrong, but I see the vaccine (if it actually happens) being only partially successful: there will be the anti-vaxxers not getting them because stupid, then there will be those in denial about COVID being real because of different stupid, then there will be those that can't be bothered, then there will be those that follow some dipshit politician who publicly is against the vaccine and thus they will be against the vaccine, and then there will be some poorly understood information that comes out indicating that the vaccine is not 100% effective and you'll need to get it yearly or multiple times a year and so it probably isn't any good like that flu vaccine once where they got the strain wrong.....blah, blah, blah. Oh, and Bill Gates tinfoil hat shit. So I'm still putting my money on less than 50% get it here (probably well over 90% in every other country that has $1 to their name).

 

[Say Hey Kid]

Hey @DaveG An interfaith coalition is trying to force Brahma beer to change it's name. I see the name as a tribute, but I guess I'm not PC enough.

 

[Boom Boom Apathy]

Hey @DaveG An interfaith coalition is trying to force Brahma beer to change it's name. I see the name as a tribute, but I guess I'm not PC enough.

I think it’s BULL shit. A bunch of CHICKENS.

 

[Sens1Canes2]

I never made a point of getting the flu shot, mainly because I've never had the flu and it seemed like 50/50 odds that it would really help anyway. It just never felt like it was worth the trouble.

Until all this happened, it never dawned on me that I could carry an illness without actually showing symptoms. I knew about Typhoid Mary and was aware, at a theoretical level, that things like that can happen. But I had no idea how common it was, so I never connected the dots on a personal level until the coronavirus came along and gave us all a crash course on epidemiology.

Now, I don't know if I've managed to go my entire life without ever being exposed to the flu, but it seems unlikely (especially since my wife has had it twice in the six years that we've known each other). But now that I'm aware of asymptomatic spread, I'll be getting the shot every year. It serves the same purpose as wearing a mask, and my thoughts on that are pretty well-documented here.

Hopefully there are others with a similar story that will drive up the take rate on vaccines.

We never had the flu shot in Canada growing up. Once I came here, stayed, and started adulting (with kids), I started hearing about it.

 

[Unsustainable]

FDA investigates MicroGen DX lab as COVID-19 test results questioned

 

[hblueridgegal]

 

[Blueline Bomber]

One of NC's private schools reopened on Monday. They've already had someone test positive for the virus.

 

[A Star is Burns]

One of NC's private schools reopened on Monday. They've already had someone test positive for the virus.

 

[SlavinAway]

I'm going to participate in a phase 3 vaccine trial.

 

[Navin R Slavin]

I'm going to participate in a phase 3 vaccine trial.

Excellent! Will you be able to talk about it?

 

[tarheelhockey]

Excellent! Will you be able to talk about it?

Only till they put him on the ventilator

 

[MrazeksVengeance]

Since the flu shot got brought up... if anyone wants to explain in layman's terms why it doesn't always work, but why it is still good to get one, I am here.

 

[SlavinAway]

Excellent! Will you be able to talk about it?

Here is what I know so far A Study to Evaluate Efficacy, Safety, and Immunogenicity of mRNA-1273 Vaccine in Adults Aged 18 Years and Older to Prevent COVID-19 - Full Text View - ClinicalTrials.gov

Quite a few sites participating in NC

University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27599

Tryon Medical Partners
Charlotte, North Carolina, United States, 28210

Carolina Institute for Clinical Research - M3 Wake Research
Fayetteville, North Carolina, United States, 28304

M3 Wake Research, Inc - M3 Wake
Raleigh, North Carolina, United States, 27612

Trial Management Associates
Wilmington, North Carolina, United States, 28403

Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157

 

[Navin R Slavin]

Here is what I know so far A Study to Evaluate Efficacy, Safety, and Immunogenicity of mRNA-1273 Vaccine in Adults Aged 18 Years and Older to Prevent COVID-19 - Full Text View - ClinicalTrials.gov

Quite a few sites participating in NC

University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27599

Tryon Medical Partners
Charlotte, North Carolina, United States, 28210

Carolina Institute for Clinical Research - M3 Wake Research
Fayetteville, North Carolina, United States, 28304

M3 Wake Research, Inc - M3 Wake
Raleigh, North Carolina, United States, 27612

Trial Management Associates
Wilmington, North Carolina, United States, 28403

Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157

First bullet point in inclusion criteria: "Participants who are at high risk of SARS-CoV-2 infection, defined as adults whose locations or circumstances put them at appreciable risk of exposure to SARS-CoV-2 and COVID-19."

That lets me out because I ain't leavin' the damn house. Are you, like, a teacher or something?

 

[Navin R Slavin]

And also, can people actually sign up somewhere?

 

[SlavinAway]

First bullet point in inclusion criteria: "Participants who are at high risk of SARS-CoV-2 infection, defined as adults whose locations or circumstances put them at appreciable risk of exposure to SARS-CoV-2 and COVID-19."

That lets me out because I ain't leavin' the damn house. Are you, like, a teacher or something?

My wife is an ICU nurse; other than that I don't leave the house but I guess that was enough.

And also, can people actually sign up somewhere?

I just looked up the website of my local participating site and they had a contact form I filled out expressing interest.

 

[Navin R Slavin]

My wife is an ICU nurse; other than that I don't leave the house but I guess that was enough.

Wow, more than enough. Good on her and you. Hope it works out well.

 

[tarheelhockey]

Since the flu shot got brought up... if anyone wants to explain in layman's terms why it doesn't always work, but why it is still good to get one, I am here.

No medicine is 100% effective. People have allergies, immune system problems, things that are specific to one person or group.

In the case of vaccines, there's an added element that it's a game of cat-and-mouse with an illness that's constantly mutating. There's not a lot to be done if a new strain of flu shows up at the beginning of flu season, after people have already had their shots.

It's still good to get one because even if it's a bad year and the flu shot is, let's say 30% effective, that's still 30% who stop the virus from spreading. Which means a lot fewer people get it in the long run.

 

[Novacane]

I’ll be planning to get the vaccine regardless but I’ve been thinking about this a bit, so I thought I’d ask my more knowledgeable forum pals

Will these shorter term trials be able to predict any long term health effects? Is there anything unique about the virus/vaccine that would make vaccine candidates more complex and susceptible to causing problems compared to, say, the typical flu vaccine?

What I struggle with is that I’m “young and healthy”, and I somewhat fear facing something later in life caused from the vaccine. However, I also recognize the need to get it for the obvious consequences of COVID and out of respect to everyone around me. I’m just a bit uninformed at the moment. I’m assuming most of this isn’t known yet unless you’re part of the trial, and it’s disclosed to you, so I’ll probably have to ask this again once the specific vaccine candidate is identified and available. Have you all heard much about this?

 

[MrazeksVengeance]

No medicine is 100% effective. People have allergies, immune system problems, things that are specific to one person or group.

In the case of vaccines, there's an added element that it's a game of cat-and-mouse with an illness that's constantly mutating. There's not a lot to be done if a new strain of flu shows up at the beginning of flu season, after people have already had their shots.

It's still good to get one because even if it's a bad year and the flu shot is, let's say 30% effective, that's still 30% who stop the virus from spreading. Which means a lot fewer people get it in the long run.

Not exactly in all cases. There is zero need to change many vaccines because the pathogen they protect against is rather stable. The thing with influenza is the devilish small size simplicity of that thing. Flu changes all the time, so the vaccine has to be made for the expected most prevalent strain that might cause the epidemic or pandemic. The majority of current-day vaccines on the market have above 90% efficiency, many of them being above 99%.

Flu shot just can't do these numbers.

 

[Sens1Canes2]

One of NC's private schools reopened on Monday. They've already had someone test positive for the virus.

I think I read that it was a visiting teacher from Tennessee, same private school company but not one “stationed” at the Raleigh location. Why he/she was there, I’m not sure.

 

[tarheelhockey]

Not exactly in all cases. There is zero need to change many vaccines because the pathogen they protect against is rather stable. The thing with influenza is the devilish small size simplicity of that thing. Flu changes all the time, so the vaccine has to be made for the expected most prevalent strain that might cause the epidemic or pandemic. The majority of current-day vaccines on the market have above 90% efficiency, many of them being above 99%.

Flu shot just can't do these numbers.

Exactly. Most years it’s completely fine. There was a year, I think maybe 2013 or some time around then, when the flu shot “failed” to a rate under 50%. Even in those cases, the 50% still goes a long way toward community management of the spread.

When it comes to vaccines, perfect should not be made the enemy of good.

 

[Boom Boom Apathy]

Exactly. Most years it’s completely fine. There was a year, I think maybe 2013 or some time around then, when the flu shot “failed” to a rate under 50%. Even in those cases, the 50% still goes a long way toward community management of the spread.

When it comes to vaccines, perfect should not be made the enemy of good.

IIRC, It was only a couple years ago that it was less than 20%

edit: it was 14/15

Past Seasons Vaccine Effectiveness Estimates | CDC

 

[Lempo]

Will these shorter term trials be able to predict any long term health effects? Is there anything unique about the virus/vaccine that would make vaccine candidates more complex and susceptible to causing problems compared to, say, the typical flu vaccine?

In a bad case scenario, anything surprising can happen in a hasty mass vaccination, like with the Pandemrix swine flu vaccination where a number of individuals of certain European folks, through a specific genetic quirk or somesuch, ended up getting narcolepsy.

 

[Boom Boom Apathy]

In a bad case scenario, anything surprising can happen in a hasty mass vaccination, like with the Pandemrix swine flu vaccination where some individuals of certain European folks, through a specific genetic quirk or somesuch, ended up getting narcolepsy.

That wasn’t a side effect. Those people pissed off Bill Gates so he just reprogrammed the microchip to put them into sleep mode.