Would be a gamechanger for Columbus's perception league-wide if they can get EK to waive his No-Trade and sign him long-term. Historically, major acquisitions have not been happy there (Jeff Carter and apparently now Panarin), although Seth Jones did re-up.
Can't really see what Columbus would be willing to part with for him. They'd be crazy to include any of Werenski and Jones, and I don't think they can afford to trade Dubios due to lack of center-depth. Only way I really see this working is a 3-way deal that gets Panarin somewhere he is happy with an extension, and Columbus slightly adds. They don't really have a prospect pool with any blue-chippers, and most of the young NHL talent they have, they shouldn't be trading (PLD, Werenski and Jones).