So you want to use a 2 game sample size to discuss shot differential when Nurse has a +88 shot differential at even strength compared to a -6 shot differential for Zadorov this year? Advanced stats are not something that you should be bringing up if you're trying to make a solid argument for Zadorov in this discussion.
With that said, this is close, but I'd give Nurse the edge because he's just straight up putting up better possession metrics while playing more minutes and is +13 on a -20+ team. Both are great young D, but Nurse is a bit better imo.
Advanced stats are definitely something that should be brought up to to pump Zadorov. He's the best possession defenseman on the Avalanche. His CF relative to his team is on par with Nurse. He's also at a 37% zone stat percentage compared to Nurses 51%.
Zadorov had a rough injury last year which he dealt the offseason rehabbing from. Then he didn't have a contract and showed up to camp late. He wasn't ready to play and was kept out of the lineup a fair bit throughout the first few weeks of the season. Since being incorporated back into the lineup full time (26 games ago) he's at a CF of 52.57, and a high danger CF of 56.91%.
Nurse's advanced stats are nice, but factoring in zone starts and team relative stats it pretty much balances out with Zadorov. Especially if you want to look at Zadorov since he started playing full time but that's not completely fair since even though we're aware of the injury and all, he still played and you need to prove yourself over a sample size. Still definitely notworthy though.
One place where Nurse does one up Zadorov is individual shot attempts. While Zadorov is very good in this area, Nurse is simply better. He's producing shots at a very very high level.
Aside from that, seeing anybody in this thread trying to straight up call one better than the other is almost certainly a fan showing some homerism. I made a post earlier saying how similar these two are in so many ways and this post adds to it. I voted Zadorov because I'm and Avalanche fan and I want him to win the poll, but that's it. If there was an "even" option I would have chosen that but since there isn't I'm voting for my guy.